Synergistic insecticidal compositions



United States Patent Office 2,995,488 Patented Aug. 8, 1961 2,9954%SYNERGISTIC INSECIKJIDAL COMPtBITIONS Howard A. Jones and John A.German, Baltimore, Md

and Berton C. Dickinson, Lyndonvllle, N.Y., rs

to Food Machinery and Chemical Corporation, New

The combinations are highly etfective and economical to use for suchlarge-scale insecticidal requirements as the control of truck crop,forage crop and orchard insects.

The synergistic compositions of this invention can be York, N.Y., acorporation of Delaware 5 formulat a g ag a g- R-: in eng: M 2;. 1 sders, as $223: 2:?5233111252325: i i iiilf ii's 1958, sen N5. 3 and 993, insecticidal compositions'can be utilized as sprays, as

2 Claims. (CL 167 3o) dusts, as aerosol mixtures, insecticidal coatingcomposio trons, and as residues. In general, they can be applied Thisinvention relates broadly to insecticidal composiby methods commonlyusedfor control or eradication t1ons, a nd more particularly to insecticidalcompositions of insects, mites and the like. .Thus these insecticidalcontaining ethyl N-benzylcarbamate and 0,0-diethyl O- compositions canbe formulated with solvents, diluents 7 (3-chloro-4-methylcoumaryl))thiophosphate, hereinand carrier media, adhesives, spreading, wettingand emulafter referred to as B-2l/ 199. More particularly, this iny gagents a other ingredientsvention relates to synergistic insecticidalcompositions of The relative proportions of the active ingredients asthese compounds wherein the insecticidal efiectiveness of well as inertcarriers, solvents, dispersants and the like each component is enhancedby the presence of the other may vary within wide limits. to produce anunexpected combined effect. Thus the relative proportion (ratio) of theB-21/199 When two or more substances in combination show an to the ethylN-benzylcarbamate can range from 20 parts unexpectedly high activity,as, for instance, insecticidal of the former per 1 part of the latter to1 part of the activity, the resulting phenomenon is called synergism.former per 40 parts of the latter and preferably about The mechanism ofsynergism is by no means understood. 1 part of the former to about 5parts of the latter. It IS, in fact, quite probable that it ditfers withdiflerent The quantities of the component toxicants in the finalsynergistic combinations. The term "synergism can be 5 insecticidalcompositions can range from 0.01% to defined, however, as a cooperativeaction which is en- 25.00% for the B-21/ 199 and'from 0.05% to 50.00%countered in combinations of two or more biologically for the carbamate,and preferably from 0.10% to 10.00% active components which the combinedactivity of the for the B-2l/ 199 and from 0.10% to 25.00% for the twocomponents exceeds the sum of the activities of the carbamate.components when used alone. The insecticidal activity The procedures ofthe testing. method are described of the mixed components cannot bepredicted from below. The details of the test experiments including theknown values of the individual components, but is untype of formulationand mode of application or dosing, predictable and depends on theindividual activity of and the species of insects which served as testsubjects neither. are given in the examples.

It is an objett olflhthis invirliltion to providesilnsffticidal The testmethod used is described as follows: compositions o e anced ling, power.0 er object of this invention is to produce novel compositions TURNTABLEMETHOD containing compounds capable of synergin'ng the knock- Houseflies.-This method is described in the article, down and killingproperties of individual toxicants. A Campbell and Sullivan, Soap andSanitary Chemicals, further object of this invention is to providecompositions 40 14 (6); 119-125, 149 (1938). The tests were carriedincluding a relatively toxic phosphorus containing inout with slightmodifications from the method described secticide in which superiorinsecticidal activity is obtained in the reference above.

because of the synergistic efiects, but in which the ulti- The table seais equipped with 8 towers. The period mate toxicity to warm-bloodedanimals is greatly reduced between spraying and actual exposure ofsettling mist because of the lower concentrations of the phosphorous tothe test flies is 6 seconds, and flies are exposed to the compoundsrequired when used in combination with the settling mist for 10 minutes.The sprayer is operated relatively less toxic carbamates. Other objectsand adat 5 p.s.i.g. Five milliliters of test solution are used forvantages of the invention will become apparent from the each test. Thereis a filter paper placed in the bottom of description of the inventionset forth below. each test dish containing the house flies undergoingtests.

According to this invention, there are provided syner- Mortality countsare made after 24 hours. gistic insecticidal compositions comprising0,0-diethyl The flies used in these tests were reared according 0 (7(3-chloro-4-methylcoumaryl))thiophosphate, hercto standard proceduresestablished by the Chemical Speafter called B-21/ 199, and ethylN-benz'ylcarbamate. cialties Manufacturers Association, as described inthe The synergistic insecticidal compositions of this invenarticleFeet-Grady Method" in the 1952 Soap Blue Book. tion may be used on awide variety of insect and mite The flies tested are 3 days old.

Table 1 NCOOR' Phmhm Mortality Test Test at 24 hrs. Gone I Cone. MethodSubject (percent) R R (mg. Name (mg.{

.ff'fZI: rm/199-. so .Tffiffiif: .Fffifiiff: 6t

Do ethyl.... 250 B-2l/l99 50 ...--do ..do

3 t This table demonstrates the unexpected efiectiveness of theinsecticidal compositions of this invention against house flies.

.This application is a devision of copending application Serial No.496,596 filed March 24, 1955, now abandoned, which is acontinuation-in-part of Serial No. 427,374, filed May 3, 1954, nowabandoned.

That which is claimed as patentably novel is:

1. Synergistic insecticidal compositions comprising 0,0- diethyl0-(7-(3-chloro-4-methylcoumaryl) )thiophosphate and ethylN-benzylcarbamate, wherein said components are present in the ratio ofabout five parts of said carbamate per part of said thiophosphate.

2. The method of killing insects which comprises applying to the insectsand their habitat a synergistic insecticidal composition comprising0,0-diethyl O-(7-(3-ch1oro-4-methylcoumaryl)) thiophosphate and ethylN-benzylcarbamate, wherein said components are present in the IelinekApr. 11, 1950 Gysin May 25, 1954 OTHER REFERENCES 10 King: U.S.D.A.Handbook No. 69, May 1954, pp.

Chemical Age, vol. 63, No. 1631 (1950), p. 540. Sharp: Agr. News Letter,January-February 1952, pp. 1-3

15 Roark: US. Dept. Agr. Bulletin E-344 (May 1935 Frear: Chemistry ofthe Pesticides, 3rd ed., January 1955, pp. 73-91.

2. THE METHOD OF KILLING INSECTS WHICH COMPRISES APPLYING TO THE INSECTSAND THEIR HABITAT A SYNERGISTIC INSECTICIDAL COMPOSITION COMPRISINGO,O-DIETHYL O-(7-(3-CHLORO-4-METHYLCOUMARYL)) THIOPHOSPHATE AND ETHYLN-BENZYLCARBAMATE, WHEREIN SAID COMPONENTS ARE PRESENT IN THE RATIO OFABOUT FIVE PARTS OF SAID CARBAMATE PER PART OF SAID THIOPHOSPHATE.